Exploring the Therapeutic Synergistic Intervention of Ceriops decendra with enriched protein of Cyamopsis tetragonoloba against Sreptozotocin Nicotinamide induced type-2 Diabetes

Abstract

In this study the synergistic antihyperglycemic effect of the medicinal plant Ceriops decendra stem hydro-alcoholic extract (CD) and protein component isolated from Cyamopsis tetragonoloba seed (CT) was evaluated in vitro in α-glucosidase and α-amylase inhibitory bio-assays and in vivo against streptozotocin (STZ)-nicotinamide-induced diabetic rats with metformin as reference in a 28 days standard treatment protocol. The blood serum biochemical parameters and tissue (liver and kidney) antioxidative parameters were analysed. Histopathology of pancreas was also studied. The animal groups treated with the combination of both CD and CT have demonstrated a remarkable inhibition of α-glucosidase and α-amylase activities and restoration of diabetes-induced serum biochemical and tissue antioxidant parameters with improved pancreatic histology as compared to the above groups indicating the synergistic effect. The findings of present study infers that, combination of both CD and CT exerted a synergistic action exhibiting more potent antihyperglycemic effect indicating the beneficial role of protein component in management of diabetic complications.