Supercritical Fluid for Retama Raetam Porous Film Production: A Strategy for Advancing Drug Dosage

Abstract

This proposal outlines a novel approach for fabricating porous films designed specifically for therapeutic formulations. These biodegradable films are sourced from Retama Raetam shrub branches through the innovative Supercritical Anti-Solvent (SAS) process. Renowned for their efficacy in managing hypertension and serving as diuretics, these films also excel in enhancing the entrapment of additional active ingredients. Furthermore, they enhance the entrapment of other active ingredients, thereby improving the stability and composition of tablets or capsules. Notably, the resulting film displays an exceptionally narrow and uniform distribution of pore sizes. Employing conditions of 10MPa and 40°C, carbon dioxide is utilized as the antisolvent to fabricate thin films sourced from Retama Raetam. These films boast a median area of approximately 7µm², underscoring their precise and consistent characteristics.