Hypoglycemic and hypolipidemic effects of Oligomeris linifolia in Alloxan-induced diabetic mice1

Authors

  • Aisha Ashiq 1Department of Chemistry, University of Science and Technology, Bannu, Pakistan
  • Saleem Jan 1Department of Chemistry, University of Science and Technology, Bannu, Pakistan
  • Yar Muhammad Khan 2Department of Biotechnology, University of Science and Technology, Bannu, Pakistan
  • Faizan Ullah 3Department of Botany, University of Science and Technology, Bannu, Pakistan
  • Ashok Kumar Balaraman 4Faculty of Pharmacy, MAHSA University, Bandar Saujana Putra, 42610 Jenjarom, Selangor, Malaysia
  • Abul Kalam Azad 5Faculty of Pharmacy, MAHSA University, Bandar Saujana Putra, 42610 Jenjarom, Selangor, Malaysia

DOI:

https://doi.org/10.5530/ctbp.2023.2.27

Keywords:

Oligomeris linifolia, White Albino mice, Antidiabetic activity, Lipid profile

Abstract

The current study was focused to eval-uate the hypoglycemic and hypolipidemic effect of methanolic extracts of Oligomeris linifolia in Alloxan-induced diabetic mice. Albino mice were orally treated for 15 days with methanolic extract of Oligomeris linifolia at dose of 200 mg/kg body-weight. The antidiabetic effect was an-alyzed by measuring blood glucose (BG) at 0, 3, 6, 9, 12, and 15 days. Total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), Serum Bilirubin (SBR), Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), Urea, Creatinine, and triglycerides (TG) levels at sac-rifice (day 16) were measured. Glibenclamide (10 mg/kg) was used as standard. Alloxan-in-duced diabetic mice showed adequate to sig-nificant increase in the level of BG, TC, TG, LDL-C, SBR, ALT, ALP, Urea, Creatinine, while HDL-C and body-weight were decreased as compared to control group (non-diabetic mice). Administration of plant methanolic extract to Alloxan-induced dabetic mice at a dose of 200 mg/kg body-weight resulted in a notable de-crease in BG, TC, TG, LDL-C, SBR, ALT, ALP, Urea and Creatinine whereas HDL-C level and body-weight were increased markedly after 15 days as compared to diabetic control group. The methanolic extract at the dose of 200 mg/kg, produced similar results compared to group treated with Glibenclamide.

Hypoglycemic and hypolipidemic effects of Oligomeris linifolia in Alloxan-induced diabetic mice1

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Published

22-05-2023

How to Cite

Ashiq, A. ., Jan, S. ., Khan, Y. M. ., Ullah, F. ., Balaraman, A. K. ., & Azad, A. K. (2023). Hypoglycemic and hypolipidemic effects of Oligomeris linifolia in Alloxan-induced diabetic mice1. Current Trends in Biotechnology and Pharmacy, 17(2), 901–906. https://doi.org/10.5530/ctbp.2023.2.27