Mupirocin Niosomal Gel with Bee Honey & Curcumin as Nano-Drug Delivery in Wound Healing Applications

Abstract

<p style="text-align: justify;">Wound healing research is still aiming toward complete regeneration and restoration of the skin&rsquo;s function and structure with the least amount of scarring. Controlled and target-ed medication distribution to wounds is more convenient than systemic administration, which allows for larger drug concentrations to be de-livered to the targeted site over time. The nano wound healing gel demonstrated a dependable administration strategy, excellent local tolerabil-ity, and superior drug delivery methods, which can promote faster healing. Recently, niosome formulations have been developed to reduce toxicity while increasing accumulation at the target site. Curcuma longa (CU) and honey are effective at inhibiting the growth of wound-as-sociated pathogens and hastening the healing process. The wound healing potential activity of mupirocin-loaded niosomal gel formulated with honey and curcumin, as well as their blends, by ether injection method and investigated for fur-ther studies. FTIR and DSC study reveals the compatibility of the drug and other excipients. In the case of post-approval study the param-eters evaluated are entrapment efficiency, drug content, pH, viscosity, spreadability, SEM, in-vi-tro drug release study, release kinetic study, stability study, and in-vivo wound healing study followed by histopathological study. This study aimed to create an excision wound model in al-bino rats and compare it to a commercially avail-able ointment (Mupicip by Cipla). The blended formulation (Formulation F7) was administered twice daily, and the wound healing effect was determined by the highest percentage of wound contraction, epithelisation period, and histoar-chitecture studies. The obtained results con-cluded that formulation F7 is considered as best formulation and has shown a higher percentage of wound contraction 99.08%. The histological study also confirms that formulation F7 pro-motes faster wound healing.</p>