Bioactive Components of piper betel Could be Potential anticancer Agents: A short Review on Pre-clinical Inves-Tigations and Practical Challenges

Abstract

<p style="text-align: justify;">The unmet treatment challenges such as intolerable adverse effects, massive immune suppression, and severe healthy tissue/organ toxicity with unaffordable treatment costs asso-ciated with conventional anticancer drug therapy have led to the exploration of complementary/alternative strategies to control the out bursting cases of cancer. In this context, plant-derived bioactive components have been increasingly popular as effective therapeutic options for the treatment of cancer. Phyto bioactive compo-nents (PBCs) derived from Piper betel have been shown to possess useful immune-modu-latory, antioxidant, anti-inflammatory properties both <em>in vitro</em> and<em> in vivo. </em>At present, a large vol-ume of pre-clinical studies have documented the beneficial effects of Piper betel-derived PBCs in various cancer therapy, either alone or in combi-nation with established chemo drugs. The pres-ent review aims to provide a comprehensive research data on the therapeutic effectiveness of PBCs of Piper betel against various cancers to establish its druggability. The review would be useful to provide essential evidence-based support for furthering work on large scale for-mulation development as well as future clinical studies of <em>Piper betel.</em></p>