Bioactive Components of piper betel Could be Potential anticancer Agents: A short Review on Pre-clinical Inves-Tigations and Practical Challenges

Authors

  • Bhabani Sankar Satapathy School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan Deemed to be University, Bhubaneswar, Odisha, India.
  • Sangram Keshari Biswal School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan Deemed to be University, Bhubaneswar, Odisha, India.
  • Laxmidhar Maharana School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan Deemed to be University, Bhubaneswar, Odisha, India.
  • Snigdha Pattnaik School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan Deemed to be University, Bhubaneswar, Odisha, India.

DOI:

https://doi.org/10.5530/ctbp.2023.2.29

Keywords:

Piper betel, Bioactive components, Therapeutic potential, Cancer therapy

Abstract

<p style="text-align: justify;">The unmet treatment challenges such as intolerable adverse effects, massive immune suppression, and severe healthy tissue/organ toxicity with unaffordable treatment costs asso-ciated with conventional anticancer drug therapy have led to the exploration of complementary/alternative strategies to control the out bursting cases of cancer. In this context, plant-derived bioactive components have been increasingly popular as effective therapeutic options for the treatment of cancer. Phyto bioactive compo-nents (PBCs) derived from Piper betel have been shown to possess useful immune-modu-latory, antioxidant, anti-inflammatory properties both <em>in vitro</em> and<em> in vivo. </em>At present, a large vol-ume of pre-clinical studies have documented the beneficial effects of Piper betel-derived PBCs in various cancer therapy, either alone or in combi-nation with established chemo drugs. The pres-ent review aims to provide a comprehensive research data on the therapeutic effectiveness of PBCs of Piper betel against various cancers to establish its druggability. The review would be useful to provide essential evidence-based support for furthering work on large scale for-mulation development as well as future clinical studies of <em>Piper betel.</em></p>

Mechanism of action of bioactive con-stituents of Piper betel in cancer prevention/treatment

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Published

22-05-2023

How to Cite

Satapathy, B. S., Biswal, S. K. ., Maharana, L. ., & Pattnaik, S. . (2023). Bioactive Components of piper betel Could be Potential anticancer Agents: A short Review on Pre-clinical Inves-Tigations and Practical Challenges. Current Trends in Biotechnology and Pharmacy, 17(2), 918–929. https://doi.org/10.5530/ctbp.2023.2.29