Synthesis, Spectral Characterization and In vitro Anti Cancer Activity of Pyimidine – Imidazole coupled Heterocyclic compounds against Human Lung Cancer Cell Line

Authors

  • S. Shakila Banu Department of Pharmaceutical Chemistry, Periyar College of Pharmaceutical Sciences, Tiruchirappalli, Tamil Nadu, INDIA.
  • G. Krishnamoorthy Department of Pharmaceutical Chemistry, Periyar College of Pharmaceutical Sciences, Tiruchirappalli, Tamil Nadu, INDIA.
  • R. Senthamarai Department of Pharmaceutical Chemistry, Periyar College of Pharmaceutical Sciences, Tiruchirappalli, Tamil Nadu, INDIA.
  • A. M. Ismail Department of Pharmaceutical Chemistry, Periyar College of Pharmaceutical Sciences, Tiruchirappalli, Tamil Nadu, INDIA.

DOI:

https://doi.org/10.5530/ctbp.2022.3s.74

Keywords:

Pyrimidine, Imidazole, Human Lung Cancer Cell line.

Abstract

To Explore two heterocyclic based scaffolds; Pyrimidine and Imidazole for Anticancer activity targeting Human Lung cancer cell lines. The designed compounds were synthesized and evaluated for their invitro Anticancer activity against Human Lung Cancer Cell line A549. In vitro anticancer activity revealed that 14h showed more potent anticancer activity as compared to the standard drug Sunitinib. This compound exhibited apoptosis thus, arresting the cell cycle at G0/G1 phase itself. To conclude, the above findings clearly demonstrated that the compound 14h may serve as good anticancer agent for further development.

Apoptosis Detection Assay

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Published

21-10-2022

How to Cite

Banu, S. S. ., Krishnamoorthy, G. ., Senthamarai, R., & Ismail, A. M. . (2022). Synthesis, Spectral Characterization and In vitro Anti Cancer Activity of Pyimidine – Imidazole coupled Heterocyclic compounds against Human Lung Cancer Cell Line. Current Trends in Biotechnology and Pharmacy, 16(3s), 162–170. https://doi.org/10.5530/ctbp.2022.3s.74