Synthesis, Spectral Characterization and In vitro Anti Cancer Activity of Pyimidine – Imidazole coupled Heterocyclic compounds against Human Lung Cancer Cell Line

Abstract

To Explore two heterocyclic based scaffolds; Pyrimidine and Imidazole for Anticancer activity targeting Human Lung cancer cell lines. The designed compounds were synthesized and evaluated for their invitro Anticancer activity against Human Lung Cancer Cell line A549. In vitro anticancer activity revealed that 14h showed more potent anticancer activity as compared to the standard drug Sunitinib. This compound exhibited apoptosis thus, arresting the cell cycle at G0/G1 phase itself. To conclude, the above findings clearly demonstrated that the compound 14h may serve as good anticancer agent for further development.