Syzygium cumini Protects Diabetic Wistar Rats Against Rosiglitazone-Induced Cardiotoxicity and Hepatotoxicity

Authors

  • Prashant L. Pingale Department of Pharmacology, Gokhale Education Society’s Sir Dr. M. S. Gosavi College of Pharmaceutical Education & Research, Prin. T. A. Kulkarni Vidyanagar, Nashik 422005, Maharashtra, INDIA.
  • Rupali A. Patil Department of Pharmacology, Gokhale Education Society’s Sir Dr. M. S. Gosavi College of Pharmaceutical Education & Research, Prin. T. A. Kulkarni Vidyanagar, Nashik 422005, Maharashtra, INDIA.
  • Aishwarya S. Gadkari Department of Pharmacology, Gokhale Education Society’s Sir Dr. M. S. Gosavi College of Pharmaceutical Education & Research, Prin. T. A. Kulkarni Vidyanagar, Nashik 422005, Maharashtra, INDIA.
  • Sunil. V. Amrutkar Department of Pharmacology, Gokhale Education Society’s Sir Dr. M. S. Gosavi College of Pharmaceutical Education & Research, Prin. T. A. Kulkarni Vidyanagar, Nashik 422005, Maharashtra, INDIA.

DOI:

https://doi.org/10.5530/ctbp.2022.3s.72

Keywords:

Alloxan, Antioxidant, Cardiotoxicity, Diabetes, Hepatotoxicity, Jambul, Rosiglitazone

Abstract

Syzygium cumini (Family: Myrtaceae), is known to show antioxidant, antidiabetic, cardioprotective and hepatoprotective activities in ayurvedic system of medicine. This study aims at determining in vitro and in vivo antioxidant activity of ethanolic extract of S. cumini (ESC). Effect of ESC on rosiglitazone induced cardiotoxicity and hepatoxicity in alloxaninduced diabetic rats was studied. Results of study indicated that ESC exhibited significant protection against cardiac and hepatic damage caused by rosiglitazone in alloxaninduced diabetes in rats comparable to silymarin, used as reference standard. Cardioprotective and hepatoprotective activity may be attributed to presence of antioxidant activity.

Effect of ethanolic extract of S. Cumini and RSG, alloxan on blood glucose level of rats

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Published

21-10-2022

How to Cite

Pingale, P. L., Patil, R. A. ., Gadkari, A. S. ., & Amrutkar, S. V. . (2022). Syzygium cumini Protects Diabetic Wistar Rats Against Rosiglitazone-Induced Cardiotoxicity and Hepatotoxicity. Current Trends in Biotechnology and Pharmacy, 16(3s), 139 –. https://doi.org/10.5530/ctbp.2022.3s.72

Issue

Vol. 16 No. 3s (2022): Current Trends in Biotechnology and Pharmacy

Section

Research Paper