Spectroscopic Analysis of DNA Binding Mode of Novel Schiff Base Vanadium Complex

Authors

  • Poonam R. Inamdar Department of Pharmaceutical Chemistry, School of Pharmacy, Vishwakarma University, Pune, 411048, Maharashtra, INDIA.
  • A. Sheela Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, 632014, Tamil Nadu, INDIA.

DOI:

https://doi.org/10.5530/ctbp.2022.3s.64

Keywords:

Vanadium complexes, Piperonal, Schiff base, DNA interaction, DNA binding

Abstract

Vanadium metal complexes based on wide range of the ligands have been explored at a greater extent for their various biological potential, in the recent times. Schiff bases are one of such fascinating ligands with donor sites varying according to the ketone or aldehyde group used. Based on these, a novel PS1V1, bis-vanadium complex was synthesized using schiff base backbone. It was characterized by using UV, FTIR, EPR and Mass spectral studies. The DNA binding ability of the characterized complex, PS1V1, was explored using UV and Fluorescence spectroscopic techniques. Furthermore, DNA binding mode of PS1V1 was also ascertained using competitive fluorescent displacement assay performed in the presence of minor groove biding agent, Hoeshcst.

Fluorescence Emission Studies of the Complex PS1V1 in the Presence of Hoechst- DNA

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Published

21-10-2022

How to Cite

Inamdar, P. R. ., & Sheela, A. . (2022). Spectroscopic Analysis of DNA Binding Mode of Novel Schiff Base Vanadium Complex. Current Trends in Biotechnology and Pharmacy, 16(3s), 70–74. https://doi.org/10.5530/ctbp.2022.3s.64

Issue

Vol. 16 No. 3s (2022): Current Trends in Biotechnology and Pharmacy

Section

Research Paper