Microwave irradiated green synthesis of novel isoxazole derivatives as anti-epileptic agent

Abstract

Green synthetic tools involve the design, synthesis and use of chemical substances by eliminating the generation of chemical hazards. This technique is advantageous in terms of atom economy, use of safer chemicals, energy efficient and decomposition of the waste materials to nontoxic substances which are eco-friendly. So, microwave irradiated heating method is applied for the generation of novel isoxazole derivatives. The structure of isoxazoles moiety contains three carbon atoms, one oxygen atom and one nitrogen atom in the five membered ring. Isoxazole scaffold exhibits diverse pharmacological activities such as anti-viral, antitubercular, anti-diabetic, anticancer, anthelmintic, antimicrobial, antifungal, antioxidant, antiepileptic, antipsychotic etc. A series of novel isoxazole derivatives are synthesized under microwave irradiation. By the help of microwave, the rate of the reaction is enhanced which leads to high selectivity with better product yield as compared to the conventional heating methods. The titled compounds are evaluated for their antiepileptic activity by using maximal electroshock (MES) method. The screening results revealed that some of the compounds exhibited promising antiepileptic activity as compared to the standard drug