Evaluation of Anti-Ulcer Activity of CorchorusTrilocularis Linn Plant Extract

Abstract

Herbal medicines are nowadays play-ing a significant role in the treatment of different ailments in human beings and animals. Bioac-tive molecules separated from natural sources assume a prevailing job in the development of a novel medication. The current study focused on evaluation of anti-ulcer activity of Corcho-rus trilocularis Linn plant extract. Corchorus trilocularis Linn belongs to Tiliaceae family and is rich in pharmacological properties. The plant extract was prepared using various solvents. The extract with high yield was selected for further studies. Various phytochemical compo-nents were evaluated for the selected extract. Anti-ulcer activity was evaluated using pylorus ligation, ethanol induced and aspirin induced ul-cer models on albino rats using 250mg/kg and 500 mg/kg doses. Ethanolic extract showed highest yield of 11.28%w/w. Phytochemical screening showed the presence of glycosides, alkaloids, triterpenes, phytosterols, tannins, fla-vonoids and steroids. 70% ethanolic extract of Corchorus trilocularis Linn showed dose depen-dent decrease in the ulcer index levels. 500mg/kg of 70% ethanolic extract showed 56.46% of inhibition and 250mg/kg showed 51.02% inhi-bition of ulcer index. In ethanol induced gastric ulceration, 70% ethanolic extract of Corchorus trilocularis Linn showed 41.16% and 45.58% protection from ulcers at 250mg/kg and 500mg/kg doses respectively. In aspirin induced gas-tric ulceration in rats, the 70% ethanolic extract of Corchorus trilocularis Linn showed 18.70% and 46.99% protection from ulcers at 250mg/kg and 500mg/kg doses respectively. The acid secretory parameters like total acidity and vol-ume of gastric secretions were also decreased. Thus the current study showed that Corchorus trilocularis Linn could be used as a potential an-ti-ulcer agent that could be beneficial for geri-atrics and patients under frequent medication suffering with ulcers.