Whole Cells Mediated Biocatalytic Reduction of Alpha- Keto Esters: Preparation of Optically Enriched Alkyl 2-hydroxypropanoates

Authors

  • Sowmyalakshmi Venkataraman Laboratory of Bioorganic Chemistry, Department of Biotechnology,Present Address: Crescent School of Pharmacy, B. S Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai 600 048, India
  • Anju Chadha Laboratory of Bioorganic Chemistry, Department of Biotechnology, b National Center for Catalysis Research, Indian Institute of Technology Madras, Chennai 600 036

DOI:

https://doi.org/10.5530/ctbp.2022.2s.37

Keywords:

Asymmetric reduction, Alkyl 2-oxopropanoates, Alpha-keto esters, Candida parapsilosis, Ethyl 3-bromo-2- oxopropanoate Introduction

Abstract

Biocatalytic reduction of alkyl 2-oxopropanoates were carried out by utilizing the whole cells of Candida parapsilosis ATCC 7330 to form the optically enriched alkyl 2-hydroxypropanoates with good enantiomeric excess (ee) (≤91%) and isolated yields (≤68%). Enantiomerically enriched (S)-ethyl 3-bromo-2- hydroxypropanoate thus synthesized by biocatalytic reduction of ethyl 3-bromo- 2-oxopropanoate is presented in this study for the first time in water under ambient reaction conditions in a reaction time of 4 h which is considerably less than earlier reported procedures.

Whole Cells Mediated Biocatalytic Reduction of Alpha- Keto Esters: Preparation of Optically Enriched Alkyl 2-hydroxypropanoates

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Published

20-06-2022

How to Cite

Venkataraman, S. ., & Chadha, A. (2022). Whole Cells Mediated Biocatalytic Reduction of Alpha- Keto Esters: Preparation of Optically Enriched Alkyl 2-hydroxypropanoates. Current Trends in Biotechnology and Pharmacy, 16(Supplement 1), 111–122. https://doi.org/10.5530/ctbp.2022.2s.37

Issue

Vol. 16 No. Supplement 1 (2022): Current Trends in Biotechnology and Pharmacy

Section

Research Paper