In Vitro and In Vivo Studies of Argemone mexicana Linn. Extracts Against Cobra Venom (Naja naja) Induced Toxicity

Authors

  • Jayakara Miriam School of Biosciences and Technology, Vellore Institute of Technology, Vellore 632014, India
  • Raghavan Srimathi School of Biosciences and Technology, Vellore Institute of Technology, Vellore 632014, India
  • Gurunathan Jayaraman School of Biosciences and Technology, Vellore Institute of Technology, Vellore 632014, India

DOI:

https://doi.org/10.5530/ctbp.2022.2s.25

Keywords:

Anti-ophidian, Naja naja, Medicinal plants, Edema

Abstract

In accordance to ethnobotanical reports, the plant Argemone Mexicana Linn. possess anti-ophidian properties. The current study is focussed on the inhibition property of the medicinal plant extracts against selective activities (PLA2 and hemotoxic) of Indian cobra venom. In vitro studies showed 100% PLA2 inhibition (1:50) and 100% inhibition of hemolysis activity of Naja naja venom (1:80) by methanolic extract of A. Mexicana. In vivo studies were carried out to determine the ED50 value of the selected extracts. Histopathology analysis revealed that A. mexicana methanolic extract has proved its potential to inhibit the Naja naja venom-induced toxicity and paw edema studies revealed a reduction in the toxicity upon treatment with the methanolic extract.

Graphical representation of lethality neutralization by A. mexicana methanolic extract

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Published

15-06-2022

How to Cite

Miriam, J., Srimathi, R. ., & Jayaraman, G. . (2022). In Vitro and In Vivo Studies of Argemone mexicana Linn. Extracts Against Cobra Venom (Naja naja) Induced Toxicity. Current Trends in Biotechnology and Pharmacy, 16(Supplement 1), 01–08. https://doi.org/10.5530/ctbp.2022.2s.25

Issue

Vol. 16 No. Supplement 1 (2022): Current Trends in Biotechnology and Pharmacy

Section

Research Paper