SARS-CoV-2 Associated Mutations, Strain Variations and Mortality During the First Epidemic Wave in India: A Study.

Authors

  • Neha Sharma University Institute of Biotechnology, Chandigarh University, Gharuan, Mohali, Punjab, 140413.

DOI:

https://doi.org/10.5530/ctbp.2022.2.23

Keywords:

Coronavirus, First wave, India, Mutation, SARS-COV-2, Variants

Abstract

India is no different to global health havoc created by SARS-COV-2 outbreak, although the appearance of different waves and the magnitude of losses varied. The study of the first wave on timeline is of utmost importance due to the alarming emergency and lack of preparedness to deal with the new virus which entered the gene pool. Besides, population density and RNA virus mutation rate might have led to more strain variants. In the present study, comparative analysis of thirty-nine complete or nearly-complete genomes of SARS-COV-2 during the first wave of COVID-19 in India was made and a number of mutations were observed. These observations further supported the evidence for genetic basis of rapid evolution of the virus.

Polycistronic genome of SARS-CoV-2 (a) SARS-COV-2 genome representing individ-ual ORFs. (b) 16 non-structural proteins (NSPS) are embedded in polyprotein 1ab (PP1ab) while structural proteins include S (spike), E (enve-lope), M (membrane), NC (nucleocapsid) (c) pairwise nucleotide sequence alignment of the strains showing mutations in NSPS, S and NC parts of the SARS-CoV-2 genome. Coloured ar-rows in part b and c depict mutations and are corelated with respect to position and strains, respectively.

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Published

20-05-2022

How to Cite

Sharma, N. . (2022). SARS-CoV-2 Associated Mutations, Strain Variations and Mortality During the First Epidemic Wave in India: A Study. Current Trends in Biotechnology and Pharmacy, 16(2), 253–259. https://doi.org/10.5530/ctbp.2022.2.23

Issue

Vol. 16 No. 2 (2022): Current Trends in Biotechnology and Pharmacy

Section

Research Paper