Evaluation of Anti-Inflammatory Activity of Tylophora asthmatica

Abstract

In this study, the anti-inflammatory activity of leaves of the Tylophora asthmatica (T. asthmatica) was assessed by using carrageenan induced and formalin induced paw edema model. Different extracts such as petroleum ether, chloroform and methanolic extract of the leaves of T. asthmatica were prepared using soxhlet method. Further, the extracts were identified for various phytochemical constituents and percentage yield of extract was calculated. The antiinflammatory activity of extracts was determined by using different dosages of 400 mg/kg in Wistar rats. The percentage inhibition of paw edema was determined using plethysmometer. The methanolic extract of T. asthmatica treated rats showed significantly higher antiinflammatory activity as compared to rats treated with petroleum ether and chloroform extracts. The results clearly indicated that the leaves of T. asthmatica have potent anti-inflammatory activity and it could be further used for the development of novel formulations for the management of inflammatory diseases.