Formulation and Evaluation of Fluconazole Loaded Elastic Liposomes for the Treatment of Keratomycosis

Abstract

The present study was aimed at formulating and evaluating fluconazole loaded elastic liposomes to treat keratomycosis. The elastic liposomes were formulated using thin film hydration method, by utilising different concentrations of phospholipids and different edge activators. The elastic liposomes prepared were evaluated for different parameters such as % entrapment efficiency, in vitro drug release study, polydispersity index, size and shape of vesicles. Formulation E2 was optimized on the basis of % entrapment efficiency and in vitro drug release study. The % entrapment efficiency of the optimized formulation was estimated to be 95.2, % cumulative drug release was 91.35±1.4, polydispersity index was 0.303 ± 0.03, vesicles size was 173.6± 5.9 nm and the shape of the vesicles was spherical with smooth surface. These results verified that the fluconazole loaded elastic liposomes formulated were effective against keratomycosis.