Harnessing the Antibacterial Potential of Sphagneticola trilobatato Combat Human Bacterial Infections

Balu  Vinayagamurthy; Palaniappan  Seedevi

doi:10.5530/ctbp.2026.1s.25

Authors

Balu Vinayagamurthy Department of Medical Informatics, SIMATS Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai - 602 105, Tamil Nadu
Palaniappan Seedevi Department of Medical Informatics, SIMATS Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai - 602 105, Tamil Nadu

DOI:

https://doi.org/10.5530/ctbp.2026.1s.25

Keywords:

Sphagneticola trilobata, antibacterial activity, methanolic extract, human pathogens, bioactive compounds

Abstract

This study investigates the antibacterial potential of Sphagneticola trilobata leaf extract against various clinically important human pathogens. The methanolic extract exhibited notable antibacterial activity, with the highest zone of inhibition measuring 21 mm against Salmonella typhi at a concentration of 100 μg/mL. The minimum inhibitory concentration (MIC) values for pathogens, including S. typhi, Staphylococcus aureus, Klebsiella pneumoniae, Vibrio cholerae, Klebsiella oxytoca, Escherichia coli, Salmonella Paratyphi, Proteus mirabilis, and Vibrio parahaemolyticus, were found to range from 40 to 100 μg/mL. Correspondingly, the minimum bactericidal concentration (MBC) values varied between 20 and 100 μg/mL. Phytochemical screening, supported by FT-IR and GC–MS analyses, revealed the presence of several bioactive functional compounds within the extract. The extract of broadspectrum antibacterial activity underscores its potential as a valuable candidate for the development of novel antibacterial agents. Further research is necessary to clarify its mechanisms of action and assess its applicability in therapeutic contexts.