Pharmacological Investigation of Asparagus racemosus and Boerhavia diffusa for Antidiabetic Activity in Dexamethasone-Induced Diabetic Rats

Abstract

Diabetes is a disorder with improper metabolism, characterized by higher blood glucose levels. insulin resistance or deficiency of insulin. Boerhavia diffusa, Asparagus recemosus well well-known herbs in traditional medicine. We have evaluated its potential for claim for anti-diabetic action. Boerhavia diffusa, Asparagus racemosus were collected from the local region of Raipur. Extracted by using the hydroalcoholic method of extraction. Diabetes was induced by using dexamethasone, and different pathological markers were determined. Rats weighing between 200 - 250 g are selected for the study and divided randomly into six groups: normal, diabetic, standard (glibenclamide, 2.5 mg/kg), Boerhavia diffusa (200mg/kg), Asparagus racemosus extract (200mg/kg), and one group with both the test drugs. Dexamethasone was initially given for 10 days, followed by on day 11, treatment started for the next 14 days. Treatment was given for 14 days. The result shows a significant (P ˂ 0.05) improvement in glucose, lipid profile and liver function, creatinine, and antioxidant potential parameters. Results indicate that Boerhavia diffusa, Asparagus recemosus posses anti diabetic and lipid-lowering potential, findings which support its traditional claim for therapeutic uses