Phyla Nodiflora Derived Silver Nanoparticles In Hydrogel Formulations: A New Approach To Wound Management

Authors

  • Reshma Devi Senthilnathan Research Scholar, Department of Pharmacognosy, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (DU), Porur Chennai-600116
  • Hemalatha S Professor, Department of Pharmacognosy, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (DU), Porur Chennai-600116.
  • V. Gayathri Head/Test Facility Management, Centre for Technology and Developmental Research (CEFTE), Sri Ramachandra Institute of Higher Education and Research (DU), Porur Chennai-600116
  • Komala M Professor, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced studies (VISTAS), Chennai 600117
  • R. Chandru Associate Professor, Department of General Surgery, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai-600116

DOI:

https://doi.org/10.5530/ctbp.2024.3s.19

Keywords:

Wound Healing, Wound Healing Silver Nanoparticles, Phyla nodiflora, Green Synthesis, Phytopharmaceutical Hydrogel, Malaysia

Abstract

A vital component of healthcare is wound healing, which includes the healing of both acute and chronic wounds. Prolonged inflammation brought on by immunological dysregulation, increased reactive oxygen species, and matrix metalloproteinase activity make chronic wounds difficult to heal. Recent developments release, making it appropriate for the treatment of chronic wounds. The hydrogel's biocompatibility capabilities and wound-healing were shown in In-vitro experiments, suggesting that it may find use in clinical settings for the treatment of chronic wounds in the future. in supplemented with hydrogel dressings antioxidants and immunomodulatory medicines have the potential to improve chronic wound healing. This work investigates the synthesis of green-synthesized silver nanoparticles (AgNPs) from the medicinal plant Phyla nodiflora , which has a variety of pharmacological properties, intending to develop a novel phytopharmaceutical hydrogel. Ethanolic extraction was employed to obtain bioactive compounds from Phyla nodiflora , followed by comprehensive phytochemical analysis revealing a notable amount of alkaloids, flavonoids, tannins, and phenolic compounds. The green synthesis of AgNPs has been examined by UV spectroscopy, zeta potential measurement, SEM with EDAX, and HRTEM. The hydrogels were evaluated for their pH, viscosity, homogeneity, spreadability, drug content, and release profiles. The optimized formulation demonstrated exceptional spreadability and prolonged medication

 UV Spectroscopy of synthesis silver nanoparticle  : UV Spectroscopy of synthesis silver nanoparticle

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Published

02-10-2024

How to Cite

Reshma Devi Senthilnathan, Hemalatha S, V. Gayathri, Komala M, & R. Chandru. (2024). Phyla Nodiflora Derived Silver Nanoparticles In Hydrogel Formulations: A New Approach To Wound Management . Current Trends in Biotechnology and Pharmacy, 18(3s), 240–256. https://doi.org/10.5530/ctbp.2024.3s.19