A Systematic Literature Review of Hemicellulose Based Hydrogels for Drug Delivery System- A Review

Nurul Anisah Zainuddin; Manisha Pandey; Shamima Abdul Rahman; Ruzalina Bahrin Bahrin; Najwa Mohamad

doi:10.5530/ctbp.2024.3s.2

Authors

Nurul Anisah Zainuddin Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Cyberjaya, 63000 Cyberjaya, Selangor, Malaysia
Manisha Pandey Department of Pharmaceutical Sciences, Central University of Haryana, Mahendergarh-123031 Haryana, India
Shamima Abdul Rahman Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Cyberjaya, 63000 Cyberjaya, Selangor, Malaysia
Ruzalina Bahrin Bahrin ALURTON, AgensiNuklear Malaysia (Nuklear Malaysia), 43000 Kajang, Selangor, Malaysia
Najwa Mohamad Department of Pharmaceutical Technology and Industry, Faculty of Pharmacy, University of Cyberjaya, 63000 Cyberjaya, Selangor, Malaysia

DOI:

https://doi.org/10.5530/ctbp.2024.3s.2

Keywords:

Hemicellulose, Hydrogel, Drug delivery

Abstract

Development of hemicellulose-based hydrogels have gained many interests from researchers in recent years because of their excellent biocompatibility, biodegradability, economically, and non-toxic. Hemicellulose based hydrogels possessed exclusive properties such as tuneable swelling behaviour and stimuli-responsiveness which have advantages in the preparation of potential hydrogels for drug delivery applications. This study was conducted by a systematic review process guided by PRISMA protocol, involving 20 related studies retrieved from Science Direct and PubMed, and data extraction and analysis were done by thoroughly review all the included articles. Three main themes were raised and discussed mainly focusing on the hydrogel synthesis, properties and drug delivery applications. The findings of this study had shown that hemicellulose-based hydrogels have great performance, functionality, and proven to be a promising drug carrier for controlled and sustained release drug delivery.