A Mouse Model of Primary Dysmenorrhea-Associated Mood Disorder – A Preliminary Study


  • Ju Jin Tan Faculty of Pharmaceutical Sciences
  • Yee Ching Low Faculty of Pharmaceutical Sciences
  • Audrey Siew Foong Kow Faculty of Pharmaceutical Sciences
  • Choo Shuian Por Faculty of Pharmaceutical Sciences
  • Chau Ling Tham Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia
  • Yu-Cheng Ho School of Medicine, College of Medicine, I-Shou University, Kaohsiung City, 82445, Taiwan R.O.C
  • Ming Tatt Lee [1]Faculty of Pharmaceutical Sciences, [2]Centre of Research for Mental Health and Wellbeing, UCSI University, Kuala Lumpur 56000, Malaysia




Menstrual cycle, depression, anxiety, psychological wellbeing, preclinical model


Primary dysmenorrhea, or painful menstruation, is known to affect many reproductively active females. Besides the chronic pain that affects daily well-being, the inflicted patients are exposed to a higher risk of developing mood disorders. Various clinical studies exhibited that patients with prolonged primary dysmenorrhea showed an elevated level of depression. To date, there’s no report on a representative model of primary dysmenorrhea-associated mood disorders. It is crucial for a new model to be present, as it will be a convenient tool for drug discovery. In the present study, employing an established mouse model of induced primary dysmenorrhea, we further examined the associated mood disorders via various behavioural tests, e.g., the open field test (anxiety-like behaviour), the tail suspension test (depression-like behaviour), and the social interaction test (anhedia). The findings showed that depressive and anxietylike behaviours were present in the primary dysmenorrhea-induced mice. Thus, this model has the potential to be further employed as a drug screening model for novel treatments for primary dysmenorrhea-associated mood disorders.

Tail suspension test




How to Cite

Ju Jin Tan, Yee Ching Low, Audrey Siew Foong Kow, Choo Shuian Por, Chau Ling Tham, Yu-Cheng Ho, & Ming Tatt Lee. (2023). A Mouse Model of Primary Dysmenorrhea-Associated Mood Disorder – A Preliminary Study . Current Trends in Biotechnology and Pharmacy, 17(4A (Supplement), 131–135. https://doi.org/10.5530/ctbp.2023.4s.100