An Expedition Towards Formulating Natural Face Serum with Garcinia mangostana (Mangosteen)

Abstract

The fast development of different industries has a negative impact on public health and the environment. Where the admiration for healthy skin has encouraged the cosmeceutical industry to develop quickly, the use of synthetic and harmful substances in many skin care products causes skin reactions like irritations, redness, and itching. As a result, the necessity for 100% natural formulation for skin health motivated the researchers to recognize it. This research aimed to formulate mangosteen anti-acne face serums using 100% natural excipients (green product) and evaluate their physicochemical properties. A combination of magnetic stirring and homogenization techniques was used for the serum formulation at room temperature. The stability of the formulation was satisfactory based on redispersion and pH (4.71) stability results. The serum provided good coverage with around 52% occlusive properties. The product was able to show an impressive antioxidant effect with an IC50 of 0.19mg/mL. Its antibacterial properties were observed against Staphylococcus aureus and Staphylococcus epidermidis where the Staphylococcus aureus was inhibited with a zone of inhibition of 18.03 mm. In the next stages, in-vivo studies of the product will help to move forward with commercialization.