Identification of New Dual PDE4/5 Inhibitors Using Pharmacophore Based Virtual Screening
Keywords:dual inhibitors, pharmacophore-based, virtual screening, COPD, inflammation of mucosal layer
Chronic Obstructive Pulmonary Disease (COPD) is a progressive airway obstruction disease caused due to inflammation of the airway mucosal layer. Current therapies have proved to be inadequate and thus there is high unmet medical need. Research has provided evidence that dual inhibition of Phosphodiesterase 4/5 (PDE4/5) is an effective strategy in suppressing inflammatory mediator release from cell types which express PDE4 and PDE5.
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