Unraveling the Clotting Cascade in Vitamin K Deficiency Associated Comorbidities

Abstract

The coagulation mechanism can be affected by vitamin K (VK) deficiency, a severe nutritional imbalance that is associated with a number of comorbidities. In this study, we incorporate data from the Gene Expression Omnibus (GEO) archive to provide a study into the unraveling of the clotting cascade in the context of VK deficiency. Maintaining hemostasis is crucial, and VK is an essential cofactor for the synthesis of coagulation factors. A lack of VK has been associated with a higher risk of bleeding problems and other comorbidities. In the present investigation, we utilized publicly accessible GEO datasets to examine the transcriptional alterations in genes linked with the clotting cascade when deficiency of VK and its associated conditions are involved. The results of our study suggested that there were significant variations in the expression of genes associated with fibrinolysis, vascular homeostasis, and coagulation in response to VK deficiency. These alterations were significantly connected to the risk of thrombotic and hemorrhagic episodes, as well as various diseases that have been associated with VK deficiency-associated disease phenotypes, including diabetes, placenta, prostate, hepatic, renal, and cardiovascular disorders.