Synthesis, Characterization and Antimicrobial Studies of Gabapentin Schiff Base Metal Complexes Containing Heterocyclic Ligand via Microwave-Assisted Method

Abstract

The use of microwave-assisted synthesis in the formation of coordination metal complexes has led to improved control of waste generation and reduced reaction times. In the present study, new Schiff base metal complexes of various metals, including ZrO (II), VO(II), Cr (III), Mn (II), Fe (II), Co (II), Ni (II), Cu (II), Zn (II), Cd (II), and Hg (II), were synthesized using microwave radiation. To characterize the synthesized metal complexes, several physical me thods were used, including elemental analysis, FT-IR, molar conductance, electronic spectra, 1H-NMR, ESR, magnetic susceptibility, ther mal, electrical conductivity, and XRD analysis. Elemental analysis revealed that the complexes were of the 1:1, 1:2, and 1:3 (M: L) types. The observed molar conductance values indicated that the complexes were non-electrolytes. The 1H-NMR spectral data suggested that the phenolic protons had been displaced during complexation. Thermo gravimetric analysis showed the presence of water molecules in the coordination metal complexes and confirmed the loss of water molecules in the first step, followed by the decomposition of the ligand in the subsequent step. The synthesized ligand and coordination metal complexes were also studied for their antibacterial and antifungal activity. They were tested against various bacteria and fungi, including Escherichia coli, Salmonella en teric, klebsiella pneumonia, Staphylococcus aureus, Streptococcus agalactiae, Aspergillus niger, and Aspergillus flavus. The results indicated that some of the metal complexes showed significant antibacterial and antifungal activity. Overall, the use of microwave-assisted synthesis in the formation of coordination metal complexes has led to the synthesis of new metal complexes with potential antibacterial and antifungal activity. The various physical methods used for characterization have provided valuable insights into the properties and behavior of these metal complexes.