In vitro-in vivo Simulation Studies On Capecitabine Loaded Niosomes Intended for Brain Targeting

Abstract

In silico modelling are renowned for their potential to extend the in vitro data logically into in vivo data. In the current study pk- sim simulation software by open systems pharmacology (osp) was utilized to extract in vivo data of in house developed capecitabine (cptb) niosomes formulation intended for brain targeting. The selected software allowed to consider brain as a compartment and thus estimated the correlation between simulated values and theoretical values of cptb. Various pharmacokinetic parameters of cptb namely molecular weight, solubility in water, p_ka, log p, intestinal permeability, unbound plasma fraction were provided as input parameters. Essential pharmacokinetic parameters namely c_max, t_max auc and plasma half life (t_1/2) were derived from the pk-sim software. Comparative plasma concentration time profile of experimental values vs simulated values ear-marked that there exists point to point correlation between in vitro parameters and in vivo parameters. It was also proved that the simulated values obtained were inline with the standard bibliographic pharmacokinetic parameter values of capecitabine indicating the scope for utilization of the pk sim software various other drug molecules and formulations.