Retroviral Proteases: A Potential Target for Development of Antiviral Agents

Order of Publishing in Issue: 
Volume :2
Issue :1
January, 2008 - March, 2008
Page No: 
R. L. Sawant*, M. S. Bhatia [1], Manisha R. Sawant[2] and Jyoti B. Wadekar
P.D.V.V.P.F’s College of Pharmacy, Vilad Ghat, Post MIDC, Ahmednagar – 414 111, Maharashtra, India
[1] Bharti Vidyapeeth’s College of Pharmacy, Near Chitranagari, Kolhapur – 414 003, Maharashtra, India
[2] New Arts, Commerce and Science College, Near Lal Taki, Ahmednagar – 414 111, Maharashtra, India

Abstract: Protease cuts the long chain of viral proteins produced by the host cell for assembly into a new functional virus. Retroviral proteases hasbeen identified as potential targets for structurebase drug design as its inactivation leads to the production of immature, noninfectious viral particles.Structure assisted drug developments of retroviral protease inhibitors have been resulted into ten drugs approved and others are undergoingclinical trials. High-resolution structures are now available for enzymes from human immunodeficiencyvirus type 1 and 2, simian immunodeficiency virus, feline immunodeficiency virus, rous sarcoma virus and equine infectiousanemic virus. This review summarizes the data documenting location, structures, functions and inhibition of retroviral proteases. Structure oftarget enzyme, binding of inhibitors to the target enzyme and common structural features of existinginhibitors could be useful for development of novel compounds with even more pertinent pharmacological and pharmacokinetic profile.

Retroviral proteases (RPs), structure, function, protease inhibitors (PIs).
133-141.pdf1.24 MB

To download full text articles and issues in PDF at no cost.All you have to do is fill out a brief registration form. It's easy and it's free. At any time, you may request removal of your contact information from our database.
Click here to Register | Click here if you have already registered

2018 ABAP Awards

Invitation for Nominations to 2019 ABAP Awards
The Association of Biotechnology and Pharmacy invites nominations for the following awards from the eligible talented people with proven track record and achievements on or before August 31, 2019 in the prescribed format.



Upcoming 0 events

  • No upcoming events available

User login