Metabolism and Glucose Tolerance Factor Activity of Synthetic Amino acid- Chromium Complexes in Yeast

Order of Publishing in Issue: 
Volume :4
Issue :4
October, 2010
Page No: 
K.S. Karthikeyan[1], P. Nagababu[2], K. Sivarama Sastry[2] and S. Satyanarayana[2]*
1Endocrinology and Metabolism Division, National Institute of Nutrition, Jama-i-Osmania P.O. Hyderabad – 500007, India
2Dept of Chemistry, Osmania University, Hyderabad-500 007, India

The Glucose Tolerance Factor (GTF), achromium containing complex, has been isolatedfrom yeast by Schwartz & Mertz. This wasinstrumental in the recognition of the role oftrivalent chromium, complexed to amino acids, inregulation of glucose metabolism and of activeGTF as a potential antidiabetic agent. We reportherein on newly devised simple, syntheticprocedures for soluble binary AA-Cr (1:1)complexes of known structure(s) and on theiractivities in S.cerevisiae. Lys.Cr permits postexponential growth of yeast and preventsapoptosis, unlike free lysine which inhibits postexponential growth and cell viability. Phe.Cr is abetter sole carbon source for yeast than the freeamino acid and complexation, in this case,enhances the rate of metabolism of its carbonskeleton. In addition, Phe.Cr as well as Gln.Cr,but not Lys.Cr, exhibit considerable GTF-likeactivity in yeast. The results obtained suggest thatsoluble AA.Cr are good model compounds forexploring structure activity correlations thatdetermine the role of trivalent chromium in cellularmetabolism.

GTF (Glucose Tolerance Factor), Amino acid-Chromium complexes (AA.Cr), ligands, Metabolism, Saccharomyces cerevisiae.
Paper-7.pdf244.05 KB

To download full text articles and issues in PDF at no cost.All you have to do is fill out a brief registration form. It's easy and it's free. At any time, you may request removal of your contact information from our database.
Click here to Register | Click here if you have already registered

2018 ABAP Awards

Invitation for Nominations to 2019 ABAP Awards
The Association of Biotechnology and Pharmacy invites nominations for the following awards from the eligible talented people with proven track record and achievements on or before August 31, 2019 in the prescribed format.



Upcoming 0 events

  • No upcoming events available

User login