@article{Ogunmoyole_Apanisile_Makun_Johnson_Akeem_2022, title={Vernonia amygdalina Leaf Extract Protects Against carbon tetrachloride-induced hepatotoxicity and Nephrotoxicity: Possible Potential in the Management of Liver and Kidney Diseases}, volume={16}, url={https://abap.co.in/index.php/home/article/view/657}, DOI={10.5530/ctbp.2022.4.87}, abstractNote={<p style="text-align: justify;">The rising prevalence of liver and kid-ney diseases is worrisome and constitutes a major threat to public health. The present study investigates the medicinal potentials of Ver-nonia amygdalina leaves in the management of liver and kidney diseases. Albino rats were randomly divided into five groups of 5 animals each. All experimental animals, except group I, were exposed to 3 ml/kg b.w of CCl4 and admin-istered different treatments. Groups III, IV and V each were treated with 50 mg/kg b.w, 100 mg/kg b.w. of bitter leaf extract and 100 mg/kg b.w. of silymarin respectively. Group II animals were left untreated after exposure to toxicant. Activ-ities of creatine kinase (CK), aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), as well as level of urea, uric acid and bilirubin were deter-mined in the serum and tissue homogenates. Lipid profile as well as activities of superoxide dismutase (SOD) and catalase (CAT) were also determined. Exposure to CCl4 resulted in signif-icant increase in CK, AST, ALP, ALT as well as bilirubin, urea and uric acid relative to the con-trol. Lipid profile was deranged, activities of SOD and CAT were markedly inhibited and level of GSH significantly depleted. However, treatment with <em>V. amygdalina r</em>eversed the toxic trend in a dose dependent manner comparable to animals treated with silymarin. In conclusion, V. amygd-alina leaf extract restored deranged lipid profile, distorted histoarchitecture as well as liver and kidney function markers. Hence, the plant is a potential candidate for the management of liver and kidney diseases.</p>}, number={4}, journal={Current Trends in Biotechnology and Pharmacy}, author={Ogunmoyole, Temidayo and Apanisile, Yetunde and Makun, OmowumiJayeola and Johnson, Olaitan Daniel and Akeem, Yusuff Adewale}, year={2022}, month={Nov.}, pages={540–552} }