Angiotensin-converting enzyme gene polymorphism may be a risk factor for COVID-19 clinical outcome

Order of Publishing in Issue: 
13
Volume :14
Issue :2
April, 2020 - June, 2020
Page No: 
236-240
Authors: 
Kalpana Panati[1], Surendranatha Reddy .E. C[2] and Venkata Ramireddy Narala[3,*]
Address: 
[1]Department of Biotechnology, Government College for Men, Kadapa –516004, A.P, India
Address: 
[2]Department of Genetics and Genomics, Yogi Vemana University, Kadapa – 516 005, A.P, Indi
Address: 
[3]Department of Zoology, Yogi Vemana University, Kadapa – 516 005, A.P, India
Email-ID: 
nvramireddy@gmail.com

Angiotensin-converting enzyme 1(ACE1) and ACE2 play a major role in regulation of blood pressure and electrolytic balance. They are known to express in epithelial cells of various tissues. SARS-CoV2 uses ACE2 as one of the receptors to enter into the host cells. Coronavirus infection associated decrease in the expression of ACE2 is known to associate with vasoconstriction, hypertension and other cardiovascular problems. Patients who are on ACE1 inhibitors show increased ACE2 expression, which is known to protect the lung from acute lung injury.

Keywords: 
Angiotensin-converting enzyme; polymorphism; COVID-19; spike protein.

Review on taxonomical and pharmacological status of Dolichos lablab

Order of Publishing in Issue: 
12
Volume :14
Issue :2
April, 2020 - June, 2020
Page No: 
229-235
Authors: 
Vishwajeet Singh* and Rajdeep Kudesia
Address: 
Dept. of Botany, Bundelkhand University, Jhansi

Dolichos lablab is a fancy plant in the U.S., an accepted food in Asia, Africa, and Central & S. America. Lablab seeds are no more than 1/2 inch in length at maximum & is coloured white to brown, red and black. It is a climbing plant with broad and large leaves. It condones the pH range of 5 to 7.5 and flourishes in a various type of soils like deep sands to heavy black clays. This study concentrates on the origin, chemical composition, distribution, pharmacology and taxonomic status of the aforementioned plant.

Keywords: 
Dolichos lablab, Seed, Flower, Linoleic acid, Plant.

Glaucoma : A Review

Order of Publishing in Issue: 
11
Volume :14
Issue :2
April, 2020 - June, 2020
Page No: 
217-228
Authors: 
Seema Thakur*, Neha Srivastava, Deepshikha Patle
Address: 
Faculty of Pharmaceutical Sciences, PCTE Group of Institutes, Ludhiana

Glaucoma is one of the most common ophthalmic conditions encountered in primary and secondary care. The glaucoma is a group of progressive optic neuropathies characterized by degeneration of retinal ganglion cells and resulting changes in the optic nerve head. It is usually associated with an increase in intraocular pressure (IOP) above the normal value—usually estimated at 21 mm Hg. Loss of ganglion cells is related to the level of intraocular pressure, but other factors may also play a role.

Keywords: 
Nil

First week of social lockdown versus medical care against COVID-19 - with special reference to India

Order of Publishing in Issue: 
10
Volume :14
Issue :2
April, 2020 - June, 2020
Page No: 
196-216
Authors: 
Kabita Das[1], Biswaranjan Paital[2,*]
Address: 
[1]Post Graduate Department of Philosophy, Utkal University, VaniVihar, Bhubaneswar, India
Address: 
[2]Redox Regulation Laboratory, Department of Zoology, Odisha University of Agriculture and Technology, College of Basic Science and Humanities, Bhubaneswar-751003, India

The disease caused by Coronavirus (CoV) is called as Coronavirus Disease (COVID-19). It became pandemic in 210 countries and rolling data indicate that 2,606,635 individuals are infected with the deadly pandemic disease and 713,812 have recovered, while, 182,114 have lost their lives.

Keywords: 
COVID-19;coronavirus, lockdown; India; pandemic spreading;socio-clinical management; social distancing.

Utility of trnS-trnG intergenic spacer in the molecular authentication of K. pinnatum

Order of Publishing in Issue: 
9
Volume :14
Issue :2
April, 2020 - June, 2020
Page No: 
190-195
Authors: 
Ranganadha Reddy .A[1,*], Srividya .B[1], Nair R.R[2], Vijetha .P[3], Krupanidhi .S[1], Venkateswarulu T.C[1], Abraham Peele .K[1], Venkatanarayana .A[1], Sudhakar .P[4]
Address: 
[1]Department of Biotechnology VFSTR Guntur India -522 213
Address: 
[2]Aushmath Biosciences Coimbatore, India 641046
Address: 
[3]Department of Chemical Engineering VFSTR Guntur India 522 213
Address: 
[4]Department of Biotechnology ANU Guntur India 522 510
Email-ID: 
rangaaluri@gmail.com

Kingiodendron pinnatum is an endemic and endangered tree of the southern Western Ghats belonging to the family Leguminosae and subfamily Detarioideae. Identification of any biological species is possible without the use of morphological cues through DNA barcoding. It is a molecular technology with requires relatively smaller standard DNA fragments as tags to discover or define species. The mitochondrial genome in plants evolves slowly when compared to that of animals.

Keywords: 
K.pinnatum, DNA barcoding, Intergenicspacer (IGS), trnS-trnG

Plackett-Burman design for screening of fermentation process parameters and their effects on L-methionine production

Order of Publishing in Issue: 
8
Volume :14
Issue :2
April, 2020 - June, 2020
Page No: 
182-189
Authors: 
Venkata Narayana .A[1], Venkateswarulu T.C[1,*], Ranganadha Reddy .A[1], Ranga Rao .A[1], Abraham Peele.K[1], John Babu .D[1], Asha .S[1], Sumalatha .B[2], Sudhakar .P[3]
Address: 
[1,*]Department of Biotechnology, Vignan’s Foundation for Science Technology & Research, Vadlamudi-522213, Andhra Pradesh, India.
Address: 
[2]Department of Chemical Engineering, Vignan’s Foundation for Science Technology & Research, Vadlamudi-522213, Andhra Pradesh, India.
Address: 
[3]Department of Biotechnology, Acharya Nagarjuna University, Guntur-522210, Andhra Pradesh, India.

In the present study, economical fermentation medium process was developed to achieve the maximum production of L-methionine by Corynebacterium glutamicum through screening of different nutritional and physical parameters by Plackett-Burman design. A total of eleven process variables such as plantain as carbon source, groundnut as nitrogen source, CaCO3, K2HPO4, KH2PO4, biotin, MgSO4.

Keywords: 
L-methionine, Corynebacterium glutamicum, Optimization, Plackett-Burman Design.

A comparitive study on levels of sirt 1 and antioxidant status in type 2 diabetic and diabetic nephropathic patients - A case control study

Order of Publishing in Issue: 
7
Volume :14
Issue :2
April, 2020 - June, 2020
Page No: 
174-181
Authors: 
Hari Priya .S*, Kedari G.S.R.
Address: 
Department of Biochemistry, Saveetha Medical College, Thandalam, Chennai.
Email-ID: 
kedari.gsr@gmail.com

Diabetic nephropathy is a leading cause of end-stage renal failure worldwide. Its morphologic characteristics include glomerular hypertrophy, basement membrane thickening, mesangial expansion, tubular atrophy, interstitial fibrosis and arteriolar thickening. All of these are part and parcel of microvascular complications of diabetes. Previous study evidences indicates that oxidative stress is the common denominator link for the major pathways involved in the development and progression of diabetic microas well as macro vascular complications of diabetes.

Keywords: 
Diabetes, Nephropathy, SIRT 1, Super oxide dismutase, Glutathione peroxidase.

Chromatographic fingerprint analysis of piperine in polyherbal and marketed formulation by HPTLC and GC-MS methods

Order of Publishing in Issue: 
6
Volume :14
Issue :2
April, 2020 - June, 2020
Page No: 
164-173
Authors: 
Gupta Reena* and Gupta Jitendra
Address: 
Institute of Pharmaceutical Research, GLA University, Chaumuha, Mathura-281406, Uttar Pradesh, India
Email-ID: 
rspg80@gmail.com

The standardization of polyherbomineral formulation (PHF) is significant with regard to accessthe quality of natural medicines. The current research study highlights the chromatographic fingerprint investigation of piperine in PHF by employing GC-MS and HPTLC. PHF contain piperinewhich is utilized to take care of cough and cold.

Keywords: 
Piperine, Polyherbomineral formulation, Phytomarker, market formulation, Gas Chromatography-Mass Spectroscopy, High Performance Thin Layer Chromatography

Design and evaluation of terbutaline sulphate immediate release tablets prepared by fluidized bed granulation technology

Order of Publishing in Issue: 
5
Volume :14
Issue :2
April, 2020 - June, 2020
Page No: 
156-163
Authors: 
Sayani Bhattacharyya[1], Mohan RB[2]
Address: 
[1]Department of Pharmaceutics, Krupanidhi College of Pharmacy, Bangalore
Address: 
[2]Department of Pharmaceutics Oxford College of Pharmacy, Hongasandra, Bangalore.
Email-ID: 
sayanibh@gmail.com

Objective: The aim of the present study was to develop immediate release tablets of terbutaline sulphate by using fluidized bed granulation technology intended for fast action in the treatment of asthma.

Keywords: 
Terbutaline sulphate, Asthma, Fluidized bed granulator,Immediate release tablet.

Prevalence of hepatitis B virus genotypes and sub-genotypes in north and east regions of India: DNA sequencing methodology

Order of Publishing in Issue: 
4
Volume :14
Issue :2
April, 2020 - June, 2020
Page No: 
147-155
Authors: 
Jagdish C. Kandpal[1,*], Rishendra Kumar[1], Kailash Chandra[2], Santosh Pandey[3], Tara S. Bisht[1]
Address: 
[1]Department of Biotechnology, Kumaun University Nainital, Uttarakhand, India.
Address: 
[2]Department of Biochemistry, HIMSR, Jamia Hamdard, Delhi, India
Address: 
[3]Department of Molecular Biology, CORE Diagnostics, Gurugram, Haryana, India

Introduction: Hepatitis B virus (HBV) is a highly prevalent infecting virus among liver-related diseases. The genetic distribution and identification of HBV genotypes and sub-genotypes represented a challenge to control the spread of infection. To find out molecular prevalence, the present methodology was carried out for the distribution pattern of HBV genotypes and subgenotypes in north and east regions of India. Methods: A total of 67 HBV DNA positive subjects were studied.

Keywords: 
Epidemiology, Phylogenetic analysis, Polymerase chain reaction, Sequencing.

 
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