In-vitro Antioxidant and Antilipidemic Activities of Xanthium strumarium L.

Order of Publishing in Issue: 
13
Volume :5
Issue :3
July, 2011
Page No: 
1362-1371
Authors: 
N.B.Sridharamurthy [1]*, R. Yogananda [2] and Srinivas U.
Address: 
[1] Department of Pharmacology, Dayananda Sagar College of Pharmacy, Bangalore, India
Address: 
[2] Department of Pharmaceutics, SJM college of Pharmacy, Chitradurga, India
Address: 
[3] Department of Pharmacognosy, Srinivasa College of Pharmacy, Mangalore, India

Abstract : In the present study Chloroform and alcohol extracts of Xanthium strumarium L. were evaluated for in vitro antioxidant and antilipidemicactivity by various methods namely total reducing power, scavenging of free radicals such as 1,2-diphenyl-2-picrylhydrazyl (DPPH),super oxide, nitric oxide, and hydrogen peroxide. The percentage scavenging of various free radicals were compared with standardantioxidants such as ascorbic acid and Butylated hydroxyl toluene (BHT). The extracts were also evaluated for anti-lipidemic activity in TritonWR-1339 (iso-octyl polyoxyethylene phenol)- induced hyperlipidemia in Swiss albino rats by estimating serum triglyceride, very low densitylipids (VLDL), cholesterol, low-density lipids (LDL), and high-density lipid (HDL) levels. Significant antioxidant activity was observed inall the methods, significant reduction (P < 0.01) in cholesterol at 6 and 24 h and (P < 0.05) at 48 h. There was significant reduction (P < 0.01) intriglyceride level at 6, 24, and 48 h. The VLDL level was also significantly (P < 0.05) reduced from 24 h and maximum reduction (P < 0.01)was seen at 48 h. There was significant increase (P < 0.01) in HDL at 6, 24, and 48 h. From the results; it is evident that alcohol and chloroformextracts of X. strumarium can effectively decrease plasma cholesterol, triglyceride, LDL, and VLDL and increase plasma HDL levels.

Keywords: 
Anti-lipidemic, antioxidant, X. strumarium, triton
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