Validated Area Under Curve UV Spectrophotometric Method for the Determination of Glimepiride in Tablet Formulations

Order of Publishing in Issue: 
5
Volume :11
Issue :4
October, 2017 - December, 2017
Page No: 
376-381
Authors: 
Santosh Karajgi,* Sunayana Mali, Shripad Potdar
Address: 
Department of Quality Assurance, BLDEA’s SSM College of Pharmacy and Research Centre, Vijayapur 586102, Karnataka, India.

A novel Area under curve method was developed for the quantification of Glimepiride using analytical grade methanol as solvent. Glimepiride obeys Beer’s law in concentration range 20-40 μg/ml in area between 227nm - 233nm.The recovery studies ascertained the accuracy of proposed method and result was validated according to ICH guideline. The result of analysis has been validated statistically by recovery studies. This method was successfully carried out for the estimation of Glimepiride in tablet dosage form without the interference of common excipients.

Keywords: 
Glimepiride, Area under curve method, Spectrophotometric method, UV determination.
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