Surface modified polymeric nanoparticles for brain targeted drug delivery

Order of Publishing in Issue: 
10
Volume :7
Issue :4
Regular
October, 2013
Page No: 
914-931
Authors: 
Sunita Lahkar and Malay K Das
Address: 
Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh - 786004, India
Email-ID: 
du_mkd@yahoo.co.in

The aim of any drug delivery system is not only to deliver a drug to specific site of action but also to maintain its therapeutic concentration at the targeted site. Most of the drugs used in CNS disorders cannot cross the blood brain barrier (BBB) due to their large molecular size, less lipid solubility and p-glycoprotein (p-gp) efflux mechanism resulting in low drug concentration in brain. Among the current strategies for brain targeting drug delivery, biodegradable polymeric nanoparticles are significant in delimiting the blood brain barrier, increasing the loading efficiency in brain and also reducing the peripheral toxicity. The present review emphasizes on the surface modified polymeric nanoparticles in enhancing drug delivery across the blood brain barrier.

Keywords: 
Blood brain barrier, polymeric nanoparticles, drug delivery, brain targeting, coated nanotechnology, ligand nanotechnology
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