An in silico Structural study on Bacterial Sulfite Reductase

Order of Publishing in Issue: 
4
Volume :12
Issue :4
October, 2018 - December, 2018
Page No: 
342-348
Authors: 
Rajeswara Reddy Erva[1]*, Rinku.P.Varghese[2], A.L.Prasanna[2], G.Madhunika[2], K.S.Ravi Teja[2], V.S.Santosh[2], Satish Babu Rajulapati[3]
Address: 
[1]Department of Biotechnology, National Institute of Technology Andhra Pradesh, Tadepalligudem, Andhra Pradesh, India.
Address: 
[2]School of Biotechnology, VFSTR (Deemed to be University), Vadlamudi, Andhra Pradesh, India.
Address: 
[3]Department of Biotechnology, National Institute of Technology Warangal, Warangal, Telangana, India.

Sulfur is amongst the most profuse elements on the globe and a vital component for life maintenance. Sulfite reductase plays a key role in sulfur pathway. It converts sulfite to sulfide. Reductase enzyme is present in sulfur reducing bacteria. Three organisms from Desulfovibrio species namely, D. alaskensis, D. vulgaris, Desulfovibrionaceae are used in this study. The computational analysis has been done out on the sulfite reductase enzyme form the above listed sulfur reducing bacteria using in silico tools. The study focused on mainly structural analysis, structural determination and structural validation as well. Structure of D. vulgaris is present in PDB and it is used as template for analyzing the structures of D.alaskensis and Desulfovibrionaceae using different structural validation and modelling online tools. Among the homology modeling tools used, based on the validation of structures using RAMPAGE tool, Swissmodel server gave the best models upon which the scientific community can be relayed. These modeled structures can be further used in molecular docking and molecular dynamics and simulation studies.

Keywords: 
Sulfite Reductase, Sulfur reducing bacteria, Structure analysis, Homology modeling and structural validation.
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