Role of L-Carnitine and DL- á -Lipoic acid on EEG pattern in aged Rat brain

Order of Publishing in Issue: 
Volume :2
Issue :2
March, 2008
Page No: 
M. Anusuyadevi,1,2 K.S. Jayachandran,3 and C. Panneerselvam,1*
1Department of Medical Biochemistry, Dr. ALM. PG.Institute of Basic Medical Sciences, Taramani Campus, University of Madras, Chennai – 600113, India.
2Current Address: Department of Physiology and Neurosciences, 173, Ashley Avenue, BSB204, Charleston, SC 29403, United States.
3Department of Biochemistry, Guindy Campus, University of Madras, Chennai – 600025, India

Aging is one of major risk factor for neurodegenerative disorders. Understanding the normal and healthy aging is still under progress. The analysis of brain field potentials recordedas electroencephalogram (EEG) has been proven to be one of the sensitive tools to characterize brain aging. In the present study, we examined the EEG pattern of young (4 months) and oldwistar rats (24 months old) for beta and theta wave pattern in frontal and parietal cortical lobesand also the role of Na+/K+ATPase studied in context, that altered electrical activity is coupledwith membrane bound enzyme. Further, we studied the role of antioxidants namely carnitineand lipoic acid on the electrical pattern in young and aged rats. Significant increase in beta wavepattern with a significant decrease in theta pattern (p<0.05) is observed in aged rat brain whencompared to the wave patterns observed in young subjects. However, supplementation of carnitineand lipoic acid to aged rats displayed a normal pattern as that of young rats. Young rats treatedwith carnitine and lipoic acid did not show a significant change. These observations providedan insight that carnitine and lipoic acid have an impact in normalizing electrical activity duringaging. The biological significance of the results is discussed.

Aging, EEG, Na+/K+ATPase, carnitine, Lipoic acid, oxidative stress.
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