Abstract:

This study has been designed to investigate the impact of oxidative stress on the thyroid hormones profile in the fertile and infertile females of the child bearing age. To achieve this aim 500 married female were included for this study and were divided in two groups: group I: 250 fertile married females and group II : 250 infertile married females falling between the reproductive age 25-35 yrs and having no history of any metabolic disorder. Melondialdehyde (MDA) is considered as oxidative stress marker in the present study. Thyroid profile tests (total T3, total T4 and TSH) were measured in both the groups. Results indicates from this study that level of MDA showed a significant (p > 0.0001) increase in the infertile group in comparison to the fertile group. On the other hand significant (p>0.0001) increase in the total T3, total T4 and TSH in the infertile group when compared to the fertile group. In the correlation study MDA had a significant positive correlation with the T3 (r= 0.2421,p= 0.00011) as well as with T4 (r=0.1463,p=0.020663).Similarly a significant positive correlation was also found in between the MDA and the TSH (r=0.020663,p=<0.00001). It was concluded that high value of melondialdehyde could be used as a marker for alteration in thyroid profile which is responsible for many complications including fertility rate in females.

Key Words: Infertility, Oxidative stress, Melondialdehyde, Thyroid.