Radiological: Pre-clinical Comparative study of Microbial derived Surfactants with Survanta for Treatment of Respiratory Distress Syndrome (RDS)

Order of Publishing in Issue: 
Volume :11
Issue :3
July, 2017 - September, 2017
Page No: 
Ashish[1], Jitendra Singh Parihar[2], Neeraj Sharma[3] and Mira Debnath (Das)[4]*
[1,4]School of Biochemical Engineering, [2,3]School of Biomedical Engineering Indian Institute of Technology (B.H.U), Varanasi, India-221005

Present study was to do comparative study of microbial produced surfactant with FDA approved drug survanta by using Near IR and Far IR spectroscopy this is useful for pre clinical test for RDS treatment. More recently IR spectroscopy comes as novel diagnostic tests to assess fetal lung maturity. Two spectral diagnostic windows for deep tissue imaging in Near IR spectrum (300- 1100nm) and for Far IR spectrum (1200nm- 2200nm) were used for comparable study of drug survanta with microbial produced Surfactin and Lipopeptide (Biosurfactant) from B.subtilis MTCC2423 and C.tropicalis MTCC230 respectively. Near IR spectrum (300-1100nm) shows the absorbance peak for surfactin and lipopeptide (Biosurfactant) was fall in same wavelength as survanta shows i.e, 396nm and 967nm. Far IR spectrum (1200nm-2200nm) shows that the least absorbance frequency was obtained at 1249nm for all the three surfactants. Surfactin shows minimum absorbance unit in highest dilution then followed by lipopeptide (Biosurfactant) supernatant then survanta i.e., 0.17, 0.24 and 0.42AU respectively. Surfactin and Lipopeptide (Biosurfactant) produced from B.subtilis MTCC2423 and C.tropicalis MTCC230 respectively, can be considered for RDS treatment as it clear the primarily study of radiological property of drug by comparable study with FDA approved drug survanta.

Respiratory distress syndrome, Surfactin, Lipopeptide, Near IR, Far IR.
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