Prediction of HIV-1 Protease Inhibitory Activity of (4-Hydroxy- 6-Phenyl-2-Oxo-2H-Pyran-3-yl) Thiomethanes: QSAR Study

Order of Publishing in Issue: 
Volume :3
Issue :2
April, 2009
Page No: 
V. Ravichandrana+, Abhishek K. Jaina, V.K. Mouryab and R. K. Agrawala*
Department of Pharmaceutical Sciences, Dr. H. S. Gour University, Sagar (M.P.), India b Govt. College of Pharmacy, Osmanpura, Aurangabad, Maharashtra, India
+Present Addres : Faculty of Pharmacy, AIMST University, Semeling - 08100, Kedah, Malaysia

In pursuit of better HIV-1 proteaseinhibitory agents, QSAR studies were performedon a series of (4-hydroxy-6-phenyl-2-oxo-2hpyran-3-yl) thiomethanes using WIN CAChe 6.1.Stepwise multiple linear regression analysis wasperformed to derive QSAR models which werefurther evaluated for statistical significance andpredictive power by internal and externalvalidation. The best QSAR model was selected,having correlation coefficient (R) = 0.923 andcross-validated squared correlation coefficient(q2) = 0.743. The developed best QSAR modelindicates that the hydrophobicity and ionizationpotential play an important role in the HIV-1protease inhibitory activities.

QSAR; HIV-1 protease inhibitory activity; multiple linear regressions; thiomethane.
Paper-4.pdf52.53 KB

To download full text articles and issues in PDF at no cost.All you have to do is fill out a brief registration form. It's easy and it's free. At any time, you may request removal of your contact information from our database.
Click here to Register | Click here if you have already registered

2018 ABAP Awards

Invitation for Nominations to 2019 ABAP Awards
The Association of Biotechnology and Pharmacy invites nominations for the following awards from the eligible talented people with proven track record and achievements on or before August 31, 2019 in the prescribed format.



Upcoming 0 events

  • No upcoming events available

User login