Pharmacological Profile of Antithrombotic, Fibrinolytic and Anticoagulant Drugs

Order of Publishing in Issue: 
12
Volume :7
Issue :2
April, 2013
Page No: 
696-707
Authors: 
Kamal Kishore
Address: 
Department of Pharmacy, M.J.P. Rohilkhand University Bareilly-243006 (Uttar Pradesh), India

The blood is a specialized fluid connective tissue or transport system which plays an important part in the maintenance of life. the transport of gases, nutrition, excretion, acid-base equity, body defence, water balance, clotting, regulation of body temperature, blood pressure, ionic balance and as a vehicle are the main functions of the blood. The anaemia, purpura, haemophilia, thrombosis, and clotting related disorders are the major complications of the hemopoietic system. Thrombosis is one of the leading cause of thromboembolic disorders affecting million peoples worldwide. Thromboembolic disorders such as pulmonary emboli, deep vein thrombosis, strokes and heart attacks are the main causes of morbidity and mortality in developed countries. Hence, antithrombotics play a pivotal role as agents for the prevention and treatment of thromboembolic disorders. A current list of various products having antithrombotic activity incorporated and prototype agents discussed. The antithrombotic includes specific antithrombotics agents like aspirin, cilostazol, clopidogrel, prasugrel, epoprostenol, dipyridamole, indomethacin, sulfinpyrazone, thromboxane receptor antagonists, thromboxane synthesis inhibitors, ticlopidine, terutroban, abciximab, eptifibatide, tirofiban, and non-specific antithrombotics agents like Ca2+ antagonists, ketanserin, nafazatron, α-receptor antagonists, β-blockers. The fibrinolytics like tissue plasminogen activators-streptokinase; urokinase, alteplase, duteplase, anistreplase, reteplase, saruplase, tenecteplase, snake venom, and anticoagulants also equally effective in the treatment of thrombotic disorders are discussed. This article includes general as well as recent pharmacological information on different aspects of antithrombotic, fibrinolytic and anticoagulant drugs that may be useful for their better understanding by users and health care professionals.

Keywords: 
Thrombosis, Platelets-inhibitors, t-PA, Ticlopidine, Aspirin, Warfarin, Heparin
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