Pharmacokinetics of Ivermectin (Ivermic Super®) following Single Dose Subcutaneous Administration in Cattle Calves

Order of Publishing in Issue: 
Volume :11
Issue :1
January, 2017 - March, 2017
Page No: 
Sakthi Karthikeyan, S.*, Ahmad, A. H., Bisht, K., Bhatt, N., Pandey, D., Kannan, K. and Ramasamy, T.
Department of Veterinary Pharmacology and Toxicology Govind Ballabh Pant University of Agriculture and Technology College of Veterinary and Animal Sciences, Pantnagar-263145 (Uttarakhand), India

The present study was undertaken to evaluate the pharmacokinetics of Ivermectin (Ivermic super®) 0.2 mg/kg b.wt in cattle calves. The study was conducted in four cross-bred male cattle calves (1.0-1.5 yrs in age, weighing 110±5 kg). The plasma concentration of ivermectin was determined by HPLC.The decay in plasma concentration of drug was biexponential in cattle calves. The Cmax value of 28.18 was obtained at Tmax of 4.7 days in cattle calves, following SC administration of Ivermic super®. The elimination half life (Beta HL), volume of distribution (V1_F) and AUC were calculated as19.18 days, 2.64,370.15 in cattle calves , following SC administration of Ivermic super®. A dosage regimen of 0.2 mg/kg at 14 days interval is recommended in cattle.

Cattle calf, Ivermectin, Pharmacokinetics, Subcutaneous
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