Nitric Oxide (NO) and Hydrogen Sulfide (H2S):Molecular Targets for Vascular Muscle Relaxation

Order of Publishing in Issue: 
11
Volume :9
Issue :4
November, 2015
Page No: 
411-419
Authors: 
A. S. Sherikar, M. S. Bhatia, R. P. Dhavale, N. M. Bhatia and P. B. Choudhari
Address: 
Bharati Vidyapeeth College of Pharmacy, Near Chitranagri, Kolhapur-416 013 (MS) India.

Abstract

Nitric oxide (NO) is produced in endothelial cells by nitric oxide synthase. This NO plays an important role in normal pathophysiology and homeostasis of human body. NO exerts a surfeit of biological effects in the cardiovascular system. Hydrogen sulphide (H2S) is synthesized naturally in the body from L-cysteine mainly by the activity of two enzymes, cystathionine-γ-lyase and cystathionine-β-synthetase. The H2S plays a vital role in vasorelaxation. Both NO and H2S works by different mechanism to produce the effect of vascular muscle relaxation. The present review focuses on the molecular enzymatic targets for NO and H2S for producing vascular muscle relaxation with recent advances and studies.

Keywords: 
Vasorelaxation, L-cysteine, cystathionine-γ-lyase, cystathionine-β- synthetase, (NO) nitric oxide and Hydrogen sulphide (H2S).
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