Modeled Structure of Trypanothione Synthetase of Leishmania infantum for development of novel therapeutics for leishmaniasis

Order of Publishing in Issue: 
Volume :2
Issue :2
July, 2008
Page No: 
390 -395
Bishal Kumar Singh, Nandini Sarkar and Vikash Kumar Dubey *
Department of Biotechnology, Indian Institute of Technology Guwahati- 781039, Assam, India

Trypanothione synthetase (TryS) is an important enzyme for survival of Leishmania; thus an important target for structure based drugdesign against leishmaniasis. We have constructed three-dimensional structure of the TryS of Leishmania infantum by homologymodeling with acceptable Ramachandran statistics. The modeled structure TryS is compared with human (host) glutathionesynthetase (GS) and Escherichia coli glutathionyspermidine synthase (GspS) involved in similar functions. Remarkable structuraldifference between human GS and TryS, opens a new avenue to design specific TryS inhibitor drugs against leishmaniasis without interfering GS activity. Interestingly, GS displays very littlesequence or structure identity with GspS or TryS . Since there is no success yet in solving the crystal structure of TryS of any species of Leishmania, the current modeled structure willbe used for our ongoing docking study to identify potentials inhibitors.

Structure-Function; Synthetase activity, Homology Modeling
paper 3.pdf829.41 KB

To download full text articles and issues in PDF at no cost.All you have to do is fill out a brief registration form. It's easy and it's free. At any time, you may request removal of your contact information from our database.
Click here to Register | Click here if you have already registered

2018 ABAP Awards

Invitation for Nominations to 2019 ABAP Awards
The Association of Biotechnology and Pharmacy invites nominations for the following awards from the eligible talented people with proven track record and achievements on or before August 31, 2019 in the prescribed format.



Upcoming 0 events

  • No upcoming events available

User login