Metabolism and Glucose Tolerance Factor Activity of Synthetic Amino acid- Chromium Complexes in Yeast

Order of Publishing in Issue: 
7
Volume :4
Issue :4
Regular
October, 2010
Page No: 
908-916
Authors: 
K.S. Karthikeyan[1], P. Nagababu[2], K. Sivarama Sastry[2] and S. Satyanarayana[2]*
Address: 
1Endocrinology and Metabolism Division, National Institute of Nutrition, Jama-i-Osmania P.O. Hyderabad – 500007, India
Address: 
2Dept of Chemistry, Osmania University, Hyderabad-500 007, India
Email-ID: 
ssnsarasani@gmail.com

The Glucose Tolerance Factor (GTF), achromium containing complex, has been isolatedfrom yeast by Schwartz & Mertz. This wasinstrumental in the recognition of the role oftrivalent chromium, complexed to amino acids, inregulation of glucose metabolism and of activeGTF as a potential antidiabetic agent. We reportherein on newly devised simple, syntheticprocedures for soluble binary AA-Cr (1:1)complexes of known structure(s) and on theiractivities in S.cerevisiae. Lys.Cr permits postexponential growth of yeast and preventsapoptosis, unlike free lysine which inhibits postexponential growth and cell viability. Phe.Cr is abetter sole carbon source for yeast than the freeamino acid and complexation, in this case,enhances the rate of metabolism of its carbonskeleton. In addition, Phe.Cr as well as Gln.Cr,but not Lys.Cr, exhibit considerable GTF-likeactivity in yeast. The results obtained suggest thatsoluble AA.Cr are good model compounds forexploring structure activity correlations thatdetermine the role of trivalent chromium in cellularmetabolism.

Keywords: 
GTF (Glucose Tolerance Factor), Amino acid-Chromium complexes (AA.Cr), ligands, Metabolism, Saccharomyces cerevisiae.
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