Insilico Studies of Ras Protein in Cancer

Order of Publishing in Issue: 
10
Volume :13
Issue :3
July, 2019 - September, 2019
Page No: 
346-349
Authors: 
A. Ranganadha Reddy[1], S. Krupanidhi[1], P. Sudhakar[2]
Address: 
[1]Department of Biotechnology VFSTR(Deemed to be University) Guntur 522 213
Address: 
[2]Department of Biotechnology Acharya Nagarjuna University Guntur 522 510
Email-ID: 
rangaaluri@gmail.com

Cancer can be defined as a set of cells that show uncontrollable growth, invasion and also metastasis takes place. Intracellular signaling pathways that have various functions in biological processes are regulated by Ras GTPase proteins and their down-stream effectors. These proteins causes spreading within the cell cycle and also the balance of pro- and anti-apoptotic factors are also affected. Ras controls different functions and also abnormalities and various points in the downstream signaling processes causes carcinogenesis and also the signal mechanisms can be used as therapeutic agents in treating cancer. They play a vital part in the cell development, maintenance and also transformations that are malignant. Changes in the signaling in both upstream and downstream can be caused by activating RAS. RASGRF2 gene is said to encode protein called Ras-specific guanine nucleotide-releasing factor 2. RAS GTPases can be seen in between active GTPbound state and inactive GDP-bound state .The GDP bound form transforms into active form and this is stimulated by GEFs (Guanine-nucleotide exchange factors) like RASGRFs. RAS protein structure was modeled by using SWISS MODEL and the model was validated by using PROCHECK.

Keywords: 
Cancer, RAS protein, SWISS MODEL, PROCHECK
AttachmentSize
PDF1.23 MB

 
To download full text articles and issues in PDF at no cost.All you have to do is fill out a brief registration form. It's easy and it's free. At any time, you may request removal of your contact information from our database.
Click here to Register | Click here if you have already registered

2018 ABAP Awards

Invitation for Nominations to 2019 ABAP Awards
The Association of Biotechnology and Pharmacy invites nominations for the following awards from the eligible talented people with proven track record and achievements on or before August 31, 2019 in the prescribed format.

DOWNLOAD CIRCULAR | APPLICATION FORM

AWARDS

User login