Insilico Studies of FOR20 - A Centrosomal Protein

Order of Publishing in Issue: 
5
Volume :12
Issue :4
October, 2018 - December, 2018
Page No: 
349-354
Authors: 
A. RanganadhaReddy[1]*, N. MadhanSai[1], S. Krupanidhi[1], P. Sudhakar[2], and T.C. Venkateswarulu[1]
Address: 
[1*]Department of Biotechnology, VFSTR (Deemed to be University) Guntur - 522213, India
Address: 
[2]Department of Biotechnology, Acharya Nagarjuna University Guntur - 522 510, India
Email-ID: 
rangaaluri@gmail.com

There is enough scientific evidence on microtubule playing important role in various functions, one such is chromosomal segregation, which made them as primary targets in the cancer treatment. Centrosomal proteins plays vital role in maintaining microtubule dynamics that having significant effect on various functions involving microtubule such as chromosomal segregation, intracellular transport and cell polarity. There are diverse centrosomal proteins that are involved in this biological functions inside the cell system, to name a few EB1, EB2, tau, FOR20.We aim to characterize the regulation of microtubule dynamics by FOR20 and its implication in cellular processes like mitotic cell division, apoptosis, and cell migration. We worked on FOR20 specifically with its enough facts about involvement in maintaining microtubule dynamics and in cell migration and to find whether FOR20 regulate dynamic properties of microtubules by performing computational studies. The evidence of interaction of FOR20 with microtubule is poorly understood at molecular level.
FOR20 protein structure was modeled by using SWISS MODEL and the model was validated by using PROCHECK.

Keywords: 
FOR20 protein, Centrosomal protein, SWISS MODEL, PROCHECK.
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