Influence of Electrolytes on Controlled Release Matrix Tablets of Diphenhydramine HCl

Order of Publishing in Issue: 
9
Volume :7
Issue :2
April, 2013
Page No: 
665-672
Authors: 
S. Vidyadhara*, V. Umamaheswar Rao, S.Siva Prasad, M. Babu Naik and T. Sravani
Address: 
Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, India
Email-ID: 
svidyadhara@gmail.com

Oral controlled matrix tablets of Diphenhydramine HCl were formulated by different hydrophilic polymers such as hydroxypropyl methylcellulose K15 M (HPMC K15 M), poly ethylene oxide WSR 301 (PEO WSR 301) and carbopol 940 P along with pharmaceutically acceptable electrolytes. The drug candidate selected is diphenhydramine HCl which is widely used as first generation antihistamine possessing anticholinergic, antitussive, antiemetic and sedative properties. This is mainly administered for once a day formulation for treating chronic allergic disorders and also for psychiatric disorders. Hence diphenhydramine HCl was formulated as controlled release matrix tablet formulations with several polymers by employing pharmaceutically acceptable electrolytes. Electrolytes such as sodium carbonate, magnesium carbonate and calcium carbonate were used at specific concentration (10 mg/tablet) in various formulations, while the drug to polymer concentrations were maintained at different ratios as 1:2, 1:2, 1:1 respectively. In this work a new attempt was made for in-situ interactions between drug and electrolytes were devised to control the release of highly water soluble drugs from oral hydrophilic monolithic systems. These electrolytes were used to monitor matrix swelling and gel properties. The results indicated that the drug released at a controlled rate were due to differential swelling rate and matrix stiffening and provides a uniform gel layer. These findings indicated that the swelling and gel formation in the presence of ionisable species within the hydrophilic matrices provide an attractive alternative for controlled drug delivery from a monolithic system.

Keywords: 
Diphenhydramine HCl, HPMC K15 M, PEO WSR 301, Carbopol 940 P, Sodium Carbonate, Magnesium Carbonate, Calcium Carbonate.
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