Influence of Cultural Conditions for Improved Production of Bioactive Metabolites by Streptomyces cheonanensis VUK-A Isolated from Coringa Mangrove Ecosystem

Order of Publishing in Issue: 
11
Volume :6
Issue :1
January, 2012 - March, 2012
Page No: 
99-111
Authors: 
Usha Kiranmayi Mangamuri [1], Sudhakar Poda [2], Krishna Naragani [1] and Vijayalakshmi Muvva[1]*
Address: 
[1] Department of Botany and Microbiology and [2] Department of Biotechnology, Acharya Nagarjuna University, Guntur-522510, Andhra Pradesh, India
Email-ID: 
profmvl@gmail.com

Abstract

The influence of culture conditions and the effect of environmental factors on the growth and production of bioactive metabolites by Streptomyces cheonanensis VUK-A was the focus of this study. The strain exhibited broad spectrum antimicrobial activity against Grampositive, Gram-negative, unicellular and multicellular fungi. The optimum pH and temperature for bioactive metabolite production were 7 and 30°C respectively. Production of bioactive metabolites by the strain was high in asparagine glucose broth as compared to other media tested. Studies on nutritional factors revealed that highest antimicrobial metabolite production was obtained when lactose and peptone at 1% and 0.25% were used as carbon and nitrogen sources respectively. Ninty six hours of incubation was found to be the optimum for bioactive metabolite production by the strain. As the strain exhibited potent antimicrobial activity, it may be explored for biotechnological purposes.

Keywords: 
Optimization, Bioactive metabolites, Nutritional factors, Culture conditions, Environmental Parameters.
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