High Fat Diet Influences Spatial Learning and Brain Cholinergic and Antioxidant Systems in Male Rats

Order of Publishing in Issue: 
3
Volume :8
Issue :1
January, 2014
Page No: 
18-28
Authors: 
Usha Rani, M., Chand Basha, D. and Jamuna, D.
Address: 
[1] Department of Psychology, Sri Venkateswara University, Tirupati, India.
Address: 
[2] Department of Zoology, Sri Venkateswara University, Tirupati, India.

Abstract
Diets rich in high fats have shown to exert detrimental effects on brain chemistry and cognitive functions. The present study was designed to examine the high fat (HF) diet induced age related perturbations in cholinergic and antioxidant systems of brain and associated dysfunctions in cognitive behavior of rats. Wistar albino rats (2 and 6 months) were fed with control and HF diet separately for a period of 8 weeks. It is evident that no significant changes were observed in body weight except in 7th and 8th week after consumption of HF diet. However, significant increased levels in total cholesterol and triglycerides were recorded in both 4 and 8 months age groups of HF diet fed rats. Results also showed decreased synaptosomal acetylcholinesterase (AChE) and, mitochondrial superoxide dismutase (SOD) activities where as MDA levels increased in the cortex, hippocampus and cerebellum regions of both age groups following consumption of HF diet. These HF diet induced alterations in cholinergic and antioxidant systems were greater in cortex and more pronounced at 8 months age rats. Spatial learning, memory and exploratory behaviors also decreased in 4 and 8months age groups of HF diet fed rats. In conclusion, our results suggest that HF diet-induces impairments in spatial learning and alterations in brain cholinergic and antioxidant systems in age dependent manner.

Keywords: 
high fat diet, cholinergic system, antioxidant system, behavior, brain.
AttachmentSize
Paper-3.pdf1.51 MB

 
To download full text articles and issues in PDF at no cost.All you have to do is fill out a brief registration form. It's easy and it's free. At any time, you may request removal of your contact information from our database.
Click here to Register | Click here if you have already registered

2018 ABAP Awards

Invitation for Nominations to 2019 ABAP Awards
The Association of Biotechnology and Pharmacy invites nominations for the following awards from the eligible talented people with proven track record and achievements on or before August 31, 2019 in the prescribed format.

DOWNLOAD CIRCULAR | APPLICATION FORM

AWARDS

User login