Hepatoprotective effect of leaves of Balanites roxburghii against carbon tetrachloride-induced hepatic damage in rats

Order of Publishing in Issue: 
13
Volume :3
Issue :2
April, 2009
Page No: 
219-224
Authors: 
K. Thirupathi, D.R. Krishna, B. Ravi Kumar, A.V.N. Apparao and G. Krishna Mohan*
Address: 
Department of Pharmacognosy and Centre for Ethnopharmacology, University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506009, Indiadrgkrishnamohan@yahoo.co.in

AbstractThe methanolic extract of leaves ofBalanites roxburghii (BLR) was evaluated forits hepatoprotective activity against carbontetrachloride (CCl4)-induced hepatic damage inrats. It was evaluated by measuring levels ofserum marker enzymes like serum glutamateoxaloacetate transaminase (SGOT), serumglutamate pyruvate transaminase (SGPT), alkalinephosphatase (ALP) and total bilirubin (TBR). Thehistological studies were also carried out tosupport the above parameters. Administration ofBLR (200 and 400 mg/kg, p.o.) markedlyprevented CCl4-induced elevation of levels ofserum GPT, GOT, ALP and TBR. A comparativehistopathological study of liver exhibited near tonormal architecture, as compared to CCl4-treatedgroup.The methanolic extract of leaves ofBalanites roxburghii (BLR) was evaluated forits hepatoprotective activity against carbontetrachloride (CCl4)-induced hepatic damage inrats. It was evaluated by measuring levels ofserum marker enzymes like serum glutamateoxaloacetate transaminase (SGOT), serumglutamate pyruvate transaminase (SGPT), alkalinephosphatase (ALP) and total bilirubin (TBR). Thehistological studies were also carried out tosupport the above parameters. Administration ofBLR (200 and 400 mg/kg, p.o.) markedlyprevented CCl4-induced elevation of levels ofserum GPT, GOT, ALP and TBR. A comparativehistopathological study of liver exhibited near tonormal architecture, as compared to CCl4-treatedgroup.

Keywords: 
Carbon tetrachloride; Balanites; Marker enzymes; Hepatoprotective activity.
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