Growth inhibition and induction of apoptosis in estrogen receptor-positive and negative human breast carcinoma cells by Adenocalymma alliaceum flowers
AbstractAdenocalymma alliaceum (A. alliaceum)is well known for its traditional medicinal usesand as a substitute for garlic. The methanol extractfrom A. alliaceum flowers (AAF) wasinvestigated for its growth inhibitory activity onthe estrogen receptor positive MCF-7 andestrogen receptor negative MDA-MB231 breastcancer cells by MTT assay. Treatment of breastcancer cells with different concentrations of AAFresulted in dose dependent growth inhibition witha growth inhibitory concentration (GI50) of53.1±4.1 µg/mL in MCF-7 and 23.9±3.7 µg/mLin MDA-MB-231 cells. Treatment of breastcancer cells with AAF resulted in time-dependentsequence of events marked by apoptosis, asshown by translocation of phosphatidylserine andactivation of caspase-3. Analysis of data suggeststhat AAF exerts growth inhibition on both breastcancer cells through apoptosis induction, and thatit may contain potent anticancer secondarymetabolites valuable for application in drugproducts.
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Invitation for Nominations to 2019 ABAP Awards
The Association of Biotechnology and Pharmacy invites nominations for the following awards from the eligible talented people with proven track record and achievements on or before August 31, 2019 in the prescribed format.
