Growth inhibition and induction of apoptosis in estrogen receptor-positive and negative human breast carcinoma cells by Adenocalymma alliaceum flowers

Order of Publishing in Issue: 
6
Volume :3
Issue :3
July, 2009
Page No: 
278 - 286
Authors: 
Swarna Latha Dugasania, Madhu Katyayani Balijepallib and Mallikarjuna Rao Pichika*
Address: 
International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia aAnnamacharya College of Pharmacy, Rajampeta, India

AbstractAdenocalymma alliaceum (A. alliaceum)is well known for its traditional medicinal usesand as a substitute for garlic. The methanol extractfrom A. alliaceum flowers (AAF) wasinvestigated for its growth inhibitory activity onthe estrogen receptor positive MCF-7 andestrogen receptor negative MDA-MB231 breastcancer cells by MTT assay. Treatment of breastcancer cells with different concentrations of AAFresulted in dose dependent growth inhibition witha growth inhibitory concentration (GI50) of53.1±4.1 µg/mL in MCF-7 and 23.9±3.7 µg/mLin MDA-MB-231 cells. Treatment of breastcancer cells with AAF resulted in time-dependentsequence of events marked by apoptosis, asshown by translocation of phosphatidylserine andactivation of caspase-3. Analysis of data suggeststhat AAF exerts growth inhibition on both breastcancer cells through apoptosis induction, and thatit may contain potent anticancer secondarymetabolites valuable for application in drugproducts.

Keywords: 
Adenocalymma alliaceum, breast cancer cells, apoptosis, enrichment factor, sulphur compounds
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