Growth inhibition and induction of apoptosis in estrogen receptor-positive and negative human breast carcinoma cells by Adenocalymma alliaceum flowers

Order of Publishing in Issue: 
Volume :3
Issue :3
July, 2009
Page No: 
278 - 286
Swarna Latha Dugasania, Madhu Katyayani Balijepallib and Mallikarjuna Rao Pichika*
International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia aAnnamacharya College of Pharmacy, Rajampeta, India

AbstractAdenocalymma alliaceum (A. alliaceum)is well known for its traditional medicinal usesand as a substitute for garlic. The methanol extractfrom A. alliaceum flowers (AAF) wasinvestigated for its growth inhibitory activity onthe estrogen receptor positive MCF-7 andestrogen receptor negative MDA-MB231 breastcancer cells by MTT assay. Treatment of breastcancer cells with different concentrations of AAFresulted in dose dependent growth inhibition witha growth inhibitory concentration (GI50) of53.1±4.1 µg/mL in MCF-7 and 23.9±3.7 µg/mLin MDA-MB-231 cells. Treatment of breastcancer cells with AAF resulted in time-dependentsequence of events marked by apoptosis, asshown by translocation of phosphatidylserine andactivation of caspase-3. Analysis of data suggeststhat AAF exerts growth inhibition on both breastcancer cells through apoptosis induction, and thatit may contain potent anticancer secondarymetabolites valuable for application in drugproducts.

Adenocalymma alliaceum, breast cancer cells, apoptosis, enrichment factor, sulphur compounds
6-Set - 278-286.pdf142.69 KB

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