Genome Analysis of Selected Foodborne Pathogens for Identification of Drug Targets

Order of Publishing in Issue: 
8
Volume :5
Issue :2
April, 2011
Page No: 
1134-1148
Authors: 
Sushil Kumar Shakyawar, Arun Goyal and Vikash Kumar Dubey*
Address: 
Department of Biotechnology, Indian Institute of Technology Guwahai, Guwahati-781 039, Assam, India
Email-ID: 
vdubey@iitg.ernet.in

Abstract : As the bacterial pathogens are showing growing resistance against existing antibiotics, there is an urgent requirement of pharmaceuticalcompanies for designing new and effective drugs against these pathogens causing common foodborne diseases. We have performed in-silicogenomic analysis of two virulent foodborne pathogens Listeria monocytogenes and Bacillus cereus for identification of potential drug targetsfor novel drug discovery. Our prediction found small number of genes of each pathogen to be targeted for drug designing. The gene productsare found to be involved in various important regulatory proteins, membrane proteins and hypothetical proteins of unknown function ofbacterial species. Further using KEGG pathway prediction various enzyme proteins were found which have active role in biosynthetic andmetabolic pathways. The primary goal of this study was to provide a valuable resource of drug targets to the scientific community. The currentdata is included in “Drug Targets Protein Database” developed by our group.

Keywords: 
Antimicrobial drugs; Essential proteins; Drug targets.
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